Associations of neutrophil-to-lymphocyte ratio with intracranial and extracranial atherosclerotic stenosis

作者：Yu Xie, Zhenxing Liu, Bitang Dan, Li Zou, Lei Zhang, Renwei Zhang, Huagang Li, Qi Cai, Nadire Aiziretiaili, Shanling Ren, Yumin Liu · 发表于：Frontiers in Neurology · 年份：2022 · DOI：10.3389/fneur.2022.966022 · 被引用次数：11 · 研究领域：Inflammatory Biomarkers in Disease Prognosis、Cerebrovascular and Carotid Artery Diseases、Intracranial Aneurysms: Treatment and Complications

Background Neutrophil-to-lymphocyte ratio (NLR) has been shown to be an important inflammatory maker. This study aims to investigate the association of NLR with intracranial and extracranial atherosclerotic stenosis. Methods We retrospectively recruited patients who underwent digital subtraction angiography (DSA) for evaluating intracranial/extracranial stenosis in the Zhongnan Hospital of Wuhan University from January 2017 to October 2021. Clinical characteristics, DSA data, blood routine, and lipid profile were recorded. Logistic regression was used to evaluate the association of NLR and intercranial/extracranial atherosclerotic stenosis in three aspects: distribution of stenosis, whether the stenosis is symptomatic, and degree of stenosis. Results A total of 1,129 patients were included in our analysis, with a median age of 62 y (interquartile range 55–68), and a median admission NLR of 2.39 (interquartile range 1.84–3.42). A total of 986 patients presented intracranial and/or extracranial atherosclerotic stenosis. Increased NLR were associated with intracranial stenosis [odds ratio (OR), 1.54; 95% CI, 1.27–1.85; p < 0.001], extracranial stenosis (OR, 1.56; 95% CI, 1.25–1.96; p < 0.001), and combined intracranial/extracranial stenosis (OR, 1.61; 95% CI, 1.28–2.03; p < 0.001). After adjustment of potential factors, higher NLR were independently associated with symptomatic stenosis (OR, 1.16; 95% CI, 1.05–1.27; p = 0.003) and degree of stenosis (OR, 1.32...