Microglia Heterogeneity: A Single-cell Concerto

作者：Leilei Wang, Haoran Wu, Shanshan Zhang, Dingxian He, Yi Chen, Jingxin Xue, Linya You, Qiong Liu, Wensheng Li · 发表于：Human Brain · 年份：2022 · DOI：10.37819/hb.001.001.0208 · 被引用次数：3 · 研究领域：Neuroinflammation and Neurodegeneration Mechanisms、Immune cells in cancer、Atherosclerosis and Cardiovascular Diseases

Microglia are tissue-resident macrophages of the central nervous system (CNS) that play crucial roles in development, homeostasis, and response to perturbation. Microglia react to the surrounding environment in a context-dependent manner. However, research on microglial heterogeneity is limited, given the lack of high-resolution and high-sensitivity methods. Recent studies have demonstrated the heterogeneity of microglia on a spatial-temporal scale, benefiting from the advancement of single-cell technologies. Here, we review the current knowledge about microglial diversity during physiological and pathological conditions in humans and mice.