Multifunctional Gold Nanoclusters for Effective Targeting, Near-Infrared Fluorescence Imaging, Diagnosis, and Treatment of Cancer Lymphatic Metastasis

作者：Zeyang Pang, Weixiao Yan, Jie Yang, Qizhen Li, Yuan Guo, Dejian Zhou, Xingyu Jiang · 发表于：ACS Nano · 年份：2022 · DOI：10.1021/acsnano.2c03752 · 被引用次数：102 · 研究领域：Nanocluster Synthesis and Applications、Advanced Nanomaterials in Catalysis、Nanoparticle-Based Drug Delivery

are different functional thiol ligands)-type GNCs, which display highly effective LN targeting, excellent stability and biocompatibility, and optimal body-retention time. Moreover, they can provide continuous NIR fluorescence imaging of LNs for >3 h from a single dose, making them well-suited for fluorescence-guided surgery. Importantly, we have further incorporated methotrexate, a chemotherapeutic drug, into the GNCs without affecting their LN-targeting ability. Consequently, they can significantly improve the efficiency of methotrexate delivery to target LNs, achieving excellent therapeutic efficacy with up to 4-fold lower hepatotoxicity. Thus, the GNCs are highly effective and safe theranostic nanomedicines against cancer lymphatic metastasis.