Tannic acid reduced apparent protein digestibility and induced oxidative stress and inflammatory response without altering growth performance and ruminal microbiota diversity of Xiangdong black goats

作者：Wang Zuo, Lei Yin, Lei Liu, Xinyi Lan, Jianhua He, Fachun Wan, Weijun Shen, Shaoxun Tang, Zhiliang Tan, Yanming Yang · 发表于：Frontiers in Veterinary Science · 年份：2022 · DOI：10.3389/fvets.2022.1004841 · 被引用次数：23 · 研究领域：Ruminant Nutrition and Digestive Physiology、Reproductive Physiology in Livestock、Gout, Hyperuricemia, Uric Acid

The present study was performed to evaluate the impacts of tannic acid (TA) supplementation at different levels on the growth performance, physiological, oxidative and immunological metrics, and ruminal microflora of Xiangdong black goats. Twenty-four goats were randomly assigned to four dietary treatments: the control (CON, basal diet), the low-dose TA group [TAL, 0.3 % of dry matter (DM)], the mid-dose TA group (TAM, 0.6 % of DM), and the high-dose TA group (TAH, 0.9 % of DM). Results showed that the growth performance was unaffected ( P > 0.05) by adding TA, whilst the 0.3 % and 0.6 % TA supplementation significantly decreased ( P < 0.05) the apparent digestibility of crude protein (CP) and ruminal NH 3 -N concentration, and raised ( P < 0.05) the level of total volatile fatty acid (TVFA) in rumen. The increments of alanine aminotransferase (ALT), triglyceride (TG), cortisol (CORT), total antioxidant capacity (T-AOC), interleukin (IL)-1β, IL-6, and serumamyloid A (SAA), and decrements of globulin (GLB), immunoglobulin G (IgG), cholinesterase (CHE), glutathione reductase (GR), creatinine (CRE), growth hormone (GH), high-density lipoprotein cholesterol (HDLC), and insulin-like growth factor 1 (IGF-1) to different extents by TA addition were observed. Although the Alpha and Beta diversity of rumen bacterial community remained unchanged by supplementing TA, the relative abundance of the predominant genus Prevotella_1 was significantly enriched ( P <...