Study on Risk Factors of Primary Non‐traumatic OVCF in Chinese Elderly and a Novel Prediction Model

作者：Zhenxing Wen, Xiaoyi Mo, Shengli Zhao, Zhichao Qi, Dan Fu, Shifeng Wen, Wing‐Hoi Cheung, Bailing Chen · 发表于：Orthopaedic Surgery · 年份：2022 · DOI：10.1111/os.13531 · 被引用次数：18 · 研究领域：Bone health and osteoporosis research、Spinal Fractures and Fixation Techniques、Vitamin K Research Studies

OBJECTIVE: Prevention of fragility fractures is one of the public health priorities worldwide, whilst the incidence of osteoporotic vertebral compression fractures (OVCF) continues to rise and lacks the corresponding accurate prediction model. This study aimed to screen potential causes and risk factors for primary non-traumatic osteoporotic vertebral compression fractures (NTOVCF) in the elderly by characterizing a patient population with NTOVCF and comparing it with a population of osteoporotic patients. METHODS: Between January 2013 and January 2022, 208 elderly patients with unequivocal evidence of bone fragility manifested as painful NTOVCF were enrolled, and compared with 220 patients with osteoporosis and no fractures. The demographic data, bone turnover markers, blood routine, serum biochemical values, and radiological findings were investigated. Differences between the fracture and non-fracture groups were analyzed, and variables significant in univariate analysis and correlation analysis were included in the logistic analysis to build the risk prediction model for osteoporotic vertebral fractures. Univariate analysis using student's t-tests for continuous variables or a chi-squared test for categorical variables was conducted to identify risk factors. RESULTS: No significant differences were revealed regarding age, gender, BMI, smoking, alcohol consumption, blood glucose, propeptide of type I procollagen (P1NP), and N-terminal middle segment osteocalcin (N-MID) (P >...