Recent Developments on the Roles of Calcium Signals and Potential Therapy Targets in Cervical Cancer

作者：Jiahui Lei, Fengying Deng, Hongmei Ding, Mengyu Fu, Ting Xu, Bingyu Ji, Lin Feng, Min Li, Junlan Qiu, Qinqin Gao · 发表于：Cells · 年份：2022 · DOI：10.3390/cells11193003 · 被引用次数：13 · 研究领域：Ion channel regulation and function、S100 Proteins and Annexins、Trace Elements in Health

Intracellular calcium (Ca2+) concentration ([Ca2+]i) is implicated in proliferation, invasion, and metastasis in cancerous tissues. A variety of oncologic therapies and some candidate drugs induce their antitumor effects (in part or in whole) through the modulation of [Ca2+]i. Cervical cancer is one of most common cancers among women worldwide. Recently, major research advances relating to the Ca2+ signals in cervical cancer are emerging. In this review, we comprehensively describe the current progress concerning the roles of Ca2+ signals in the occurrence, development, and prognosis of cervical cancer. It will enhance our understanding of the causative mechanism of Ca2+ signals in cervical cancer and thus provide new sights for identifying potential therapeutic targets for drug discovery.