Role of the Gut Microbiota in the Increased Infant Body Mass Index Induced by Gestational Diabetes Mellitus

作者：Qingyi Zhu, Yang Xu, Yingying Zhang, Chunjian Shan, Zhonghua Shi · 发表于：mSystems · 年份：2022 · DOI：10.1128/msystems.00465-22 · 被引用次数：38 · 研究领域：Gestational Diabetes Research and Management、Birth, Development, and Health、Infant Nutrition and Health

Using 16S rRNA sequencing analysis, regression analysis and mediation analysis were used to explore whether maternal gestational diabetes mellitus (GDM) changed the function and composition of the meconium microbiota and whether this explained the GDM-induced alterations of infant body mass index (BMI). This study showed that gut microbiome dysbiosis induced by maternal GDM might play an important role in the increased infant BMI during the first 12 months of life. Therefore, gut microbiome interventions might represent a novel technique to decrease the risk of GDM-induced childhood obesity.