Gray matter volume alterations in subjects with overweight and obesity: Evidence from a voxel-based meta-analysis

作者：Lei Li, Hua Yu, Ming Zhong, Siyi Liu, Wei Wei, Yajing Meng, Mingli Li, Tao Li, Qiang Wang · 发表于：Frontiers in Psychiatry · 年份：2022 · DOI：10.3389/fpsyt.2022.955741 · 被引用次数：21 · 研究领域：Dementia and Cognitive Impairment Research、Neural and Behavioral Psychology Studies、Eating Disorders and Behaviors

Background: Obesity is a multi-systemic disease with complex etiology. And consistent evidence indicated obesity or overweight subjects render brain structure changes. Increasing evidence indicates these subjects have shown widespread structural brain gray matter volume (GMV) changes. However, results from other neuroimaging studies have been inconsistent. Consequently, the question remains whether body mass index (BMI), a gold standard to define obesity/overweight, is associated with brain structural changes. Methods: This study will apply an updated meta-analysis of voxel-based GMV studies to compare GMV changes in overweight and obese subjects. Online databases were used to build on relevant studies published before May 2022. The updated Seed-based d Mapping with Permutation of Subject Images (SDM-PSI) explores GMV changes in individuals with overweight and obesity and further examines the correlation between GMV and obesity-related variables, specifically body mass index (BMI). Results: This research included fourteen studies and provided a whole-brain analysis of GMV distribution in overweight and obese individuals. It revealed lower GMV in brain regions, including the left putamen and right precentral gyrus, in individuals with overweight and obesity compared to lean controls. Further, meta-regression analyses revealed GMV in the left middle occipital gyrus was negatively correlated with the BMI of the whole sample. Conclusion: GMV decreased was reported in reward circu...