Pyroptosis in NLRP3 inflammasome-related atherosclerosis

作者：Xiang Zeng, Dongling Liu, Xia Huo, Yue Wu, Cuiqing Liu, Qinghua Sun · 发表于：Cell Stress · 年份：2022 · DOI：10.15698/cst2022.10.272 · 被引用次数：38 · 研究领域：Inflammasome and immune disorders、Gout, Hyperuricemia, Uric Acid、Kawasaki Disease and Coronary Complications

Pyroptosis is a proinflammatory form of programmed cell death in response to inflammation. It involves in the pathogenesis and outcomes of atherosclerosis characterized by NLRP3 inflammasome assembly, membrane pore formation, cell swelling, pro-inflammatory mediator and cytokine release. There are known pyroptosis molecular pathways including the caspase-1 depended canonical signaling pathway and the caspase-4/5/11 determined non-canonical signaling pathway. It is essential to explore the connection among NLRP3 inflammasome, pyroptosis and atherosclerosis, which may shed light on the potential therapeutic strategies that target pyroptosis in atherosclerotic treatment.