Invasive pneumococcal disease surveillance in Canada, 2020

作者：Alyssa Golden, Averil Griffith, Walter Demczuk, Brigitte Lefebvre, Allison McGeer, Gregory J. Tyrrell, George G. Zhanel, Julianne V. Kus, Linda Hoang, Jessica Minion, Paul Van Caeseele, Hanan Smadi, David J. M. Haldane, George Zahariadis, Kristen Mead, Laura Steven, Lori Strudwick, Anita Li, Michael R. Mulvey, Irene Etayo Martín · 发表于：Canada Communicable Disease Report · 年份：2022 · DOI：10.14745/ccdr.v48i09a04 · 被引用次数：22 · 研究领域：Pneumonia and Respiratory Infections、Respiratory viral infections research、Pneumocystis jirovecii pneumonia detection and treatment

Background: Invasive pneumococcal disease (IPD), which is caused by Streptococcus pneumoniae, has been a nationally notifiable disease in Canada since 2000.The use of conjugate vaccines has markedly decreased the incidence of IPD in Canada; however, the distribution of serotypes has shifted in favour of non-vaccine types.This report summarizes the demographics, serotypes and antimicrobial resistance of IPD infections in Canada in 2020.Methods: The Public Health Agency of Canada's National Microbiology Laboratory (Winnipeg, Manitoba) collaborates with provincial and territorial public health laboratories to conduct national surveillance of IPD.A total of 2,108 IPD isolates were reported in 2020.Serotyping was performed by Quellung reaction and antimicrobial susceptibilities were determined in collaboration with the University of Manitoba/Canadian Antimicrobial Resistance Alliance.Population-based IPD incidence rates were obtained through the Canadian Notifiable Disease Surveillance System.Results: Overall incidence of IPD in Canada decreased significantly from 11.5 (95% confidence interval [CI]: 10.1-13.1) to 6.0 (95% CI: 5.0-7.2), and from 10.0 (95% CI: 9.7-10.3)to 5.9 (95% CI: 5.7-6.2) cases per 100,000 from 2019 to 2020; in those younger than five years and those five years and older, respectively.The most common serotypes overall were 4 (11.2%,n=237), 3 (10.9%,n=229) and 8 (7.2%, n=151).From 2016 to 2020, serotypes with increasing trends (p<0.05)included 4 (6.4%-11.2%), 3 ...