Characterization of Phage Resistance and Their Impacts on Bacterial Fitness in Pseudomonas aeruginosa

作者：Na Li, Yigang Zeng, Mengran Wang, Rong Bao, Yu Chen, Xiaoyu Li, Jue Pan, Tongyu Zhu, Bijie Hu, Demeng Tan · 发表于：Microbiology Spectrum · 年份：2022 · DOI：10.1128/spectrum.02072-22 · 被引用次数：71 · 研究领域：Bacteriophages and microbial interactions、Vibrio bacteria research studies、Genomics and Phylogenetic Studies

Battling phage resistance is one of the main challenges faced by phage therapy. To overcome this challenge, detailed information about the mechanisms of phage-host interactions is required to understand the bacterial evolutionary processes. In this study, we identified mutations in key steps of type IV pili (T4P) and O-antigen biosynthesis leading to phage resistance and provided new evidence on how phage predation contributed toward host phenotypes and fitness variations. Together, our results add further fundamental knowledge on phage-host interactions and how they regulate different aspects of Pseudomonas cell behaviors.