The efficacy and safety of transcutaneous auricular vagus nerve stimulation in patients with mild cognitive impairment: A double blinded randomized clinical trial

作者：Lei Wang, Jinling Zhang, Chunlei Guo, Jiakai He, Shuai Zhang, Yu Wang, Yu Wang, Ya-Nan Zhao, Liang Li, Junying Wang, Liwei Hou, Shaoyuan Li, Yifei Wang, Yifei Wang, Lixiao Hao, Yufeng Zhao, Mozheng Wu, Jiliang Fang, Peijing Rong · 发表于：Brain stimulation · 年份：2022 · DOI：10.1016/j.brs.2022.09.003 · 被引用次数：143 · 研究领域：Vagus Nerve Stimulation Research、Acupuncture Treatment Research Studies、Obstructive Sleep Apnea Research

BACKGROUND: There are 9.9 million new cases of dementia in the world every year. Short-term conversion rate from mild cognitive impairment (MCI) to dementia is between 20% and 40%, but long-term in 5-10 years ranges from 60% to 100%. It is particularly important to prevent or prolong the development of MCI into dementia. Both auriculotherapy and vagus nerve stimulation are effective on improving cognitive functions. However, there is no double blinded randomized clinical trial to support the effectiveness of transcutaneous electrical stimulation of auricular acupoints in patients with MCI. METHODS: ), which are out of the distribution of vagus nerve. The primary outcome was the Montreal cognitive assessment-basic, MOCA-B. The secondary outcomes included auditory verbal learning test-HuaShan version (AVLT-H), shape trails test A&B (STT-A&B), animal fluence test (AFT), Boston naming test (BNT), Pittsburgh sleep quality index (PSQI), rapid eye movement sleep behavior disorder screening questionnaire (RBDSQ), Epworth sleepiness scale (ESS) and functional activities questionnaire (FAQ). These outcome measures were taken at baseline, 24 weeks later. RESULTS: After 24 weeks of intervention, the data of 52 patients were intended for analysis. After intervention, there was significant difference in the overall scores of MoCA-B between taVNS group and sham taVNS group (p = 0.033 < 0.05). In taVNS group, compared with before intervention, the overall scores of MOCA-B increased significa...