Genetic analysis of novel avian A(H7N9) influenza viruses isolated from patients in China, February to April 2013

作者：Tsutomu Kageyama, Seiichiro Fujisaki, Emi Takashita, H Xu, S Yamada, Yuko Uchida, Gabriele Neumann, Takehiko Saito, Yoshihiro Kawaoka, Masato Tashiro · 发表于：Eurosurveillance · 年份：2013 · DOI：10.2807/ese.18.15.20453-en · 被引用次数：312 · 研究领域：Influenza Virus Research Studies、Viral Infections and Vectors、Animal Virus Infections Studies

Novel influenza viruses of the H7N9 subtype have infected 33 and killed nine people in China as of 10 April 2013. Their haemagglutinin (HA) and neuraminidase genes probably originated from Eurasian avian influenza viruses; the remaining genes are closely related to avian H9N2 influenza viruses. Several characteristic amino acid changes in HA and the PB2 RNA polymerase subunit probably facilitate binding to human-type receptors and efficient replication in mammals, respectively, highlighting the pandemic potential of the novel viruses.