Predictors of Recurrent Venous Thrombosis After Cerebral Venous Thrombosis

作者：Liqi Shu, Ekaterina Bakradze, Setareh Salehi Omran, James A. Giles, Jordan Yardain Amar, Nils Henninger, Marwa Elnazeir, Ava Leigh Liberman, Khadean Moncrieffe, Jenny Rotblat, Richa Sharma, Yee Kuang Cheng, Adeel Shakil Zubair, Alexis Netis Simpkins, Grace Li, Justin Kung, Dezaray Perez, Mirjam R. Heldner, Adrian Scutelnic, Rascha von Martial, Bernhard Siepen, Aaron Rothstein, Ossama Khazaal, David Do, Sami Al Kasab, Line Abdul Rahman, Eva A. Mistry, Deborah Kerrigan, Hayden Lafever, Thanh N. Nguyen, Piers Klein, Hugo Javier Aparicio, Jennifer Ann Frontera, Lindsey R. Kuohn, Shashank Agarwal, Christoph Stretz, Narendra Kala, Sleiman ElJamal, Allison Chang, Shawna Cutting, Fransisca Indraswari, Adam de Havenon, Varsha Muddasani, Teddy Y. Wu, Duncan Wilson, Amre M Nouh, Daniyal Asad, Abid Y. Qureshi, Justin Moore, Pooja Kumari Khatri, Yasmin Aziz, Bryce Casteigne, Muhib Khan, Yao Cheng, Brian Mac Grory, Martin S. Weiss, Dylan Ryan, Maria Cristina Vedovati, Maurizio Paciaroni, James Ernest Siegler, Scott E Kamen, Siyuan Yu, Christopher R. Leon Guerrero, Eugenie Atallah, Gian Marco De Marchis, Alex Brehm, Tolga Dittrich, Marios Nikos Psychogios, Ronald Alvarado-Dyer, Tareq Kass‐Hout, Shyam Prabhakaran, Tristan Honda, David S. Liebeskind, Karen L. Furie, Shadi R. Yaghi · 发表于：Neurology · 年份：2022 · DOI：10.1212/wnl.0000000000201122 · 被引用次数：26 · 研究领域：Cerebral Venous Sinus Thrombosis、Systemic Lupus Erythematosus Research、Venous Thromboembolism Diagnosis and Management

Background and Objective Cerebral venous thrombosis (CVT) is a rare cause of stroke carrying a nearly 4% risk of recurrence after 1 year. There are limited data on predictors of recurrent venous thrombosis in patients with CVT. In this study, we aim to identify those predictors. Methods This is a secondary analysis of the ACTION-CVT study which is a multicenter international study of consecutive patients hospitalized with a diagnosis of CVT over a 6-year period. Patients with cancer-associated CVT, CVT during pregnancy, or CVT in the setting of known antiphospholipid antibody syndrome were excluded per the ACTION-CVT protocol. The study outcome was recurrent venous thrombosis defined as recurrent venous thromboembolism (VTE) or de novo CVT. We compared characteristics between patients with vs without recurrent venous thrombosis during follow-up and performed adjusted Cox regression analyses to determine important predictors of recurrent venous thrombosis. Results Nine hundred forty-seven patients were included with a mean age of 45.2 years, 63.9% were women, and 83.6% had at least 3 months of follow-up. During a median follow-up of 308 (interquartile range 120–700) days, there were 5.05 recurrent venous thromboses (37 VTE and 24 de novo CVT) per 100 patient-years. Predictors of recurrent venous thrombosis were Black race (adjusted hazard ratio [aHR] 2.13, 95% CI 1.14–3.98, p = 0.018), history of VTE (aHR 3.40, 95% CI 1.80–6.42, p < 0.001), and the presence of one or more posi...