Antibiotics Resistance Prevalence of Helicobacter pylori Strains in Northwest China

作者：Huimei Xu, Jianwei Yun, Ruiying Li, Xueni Ma, Lingzhu Gou, Tuanjie Che, Dekui Zhang · 发表于：Infection and Drug Resistance · 年份：2022 · DOI：10.2147/idr.s383444 · 被引用次数：17 · 研究领域：Helicobacter pylori-related gastroenterology studies、Veterinary medicine and infectious diseases、Gastric Cancer Management and Outcomes

Purpose: This study aims to estimate the resistance rate of Helicobacter pylori ( HP ) to commonly used antibiotics and analyze the potential influencing factors in northwest regions of China. Patients and Methods: HP -positive patients visiting the outpatient department of multiple hospitals were enrolled in the study. Then, gastric mucosal biopsy specimens were collected for HP isolation, culture, and investigation of the resistance rate of HP to amoxicillin, metronidazole, tetracycline, levofloxacin, and clarithromycin by Epsilometer test (E-test) antibiotic susceptibility testing. In addition, multi-drug resistance, the influence of HP eradication history, age, and region of residence on drug resistance rate were analyzed. Results: In total, 198 HP clinical strains were successfully isolated and cultured. The resistance rates of amoxicillin, metronidazole, tetracycline, levofloxacin, and clarithromycin were 16.16%, 85.86%, 7.58%, 46.46%, and 55.05%, respectively. The multi-drug resistance rates demonstrated that dual and triple resistances were 30.30% and 22.73%, respectively. The quadruple resistance rate reached 9.60%. Our results revealed that the prior eradication history of HP significantly increased levofloxacin and clarithromycin resistance. Metronidazole and levofloxacin resistances significantly differed among different age groups, which presented an upward trend with increasing age. Drug resistance rates varied with geographic regions, especially amoxicillin and...