Non-HDL-C/HDL-C ratio is associated with carotid plaque stability in general population: A cross-sectional study

作者：Anran Wang, Yapeng Li, Lue Zhou, Kai Liu, Shaohua Li, Ce Zong, Bo Song, Yuan Gao, Yusheng Li, Chuansheng Tian, Yurong Xing, Yuming Xu, Longde Wang · 发表于：Frontiers in Neurology · 年份：2022 · DOI：10.3389/fneur.2022.875134 · 被引用次数：69 · 研究领域：Diabetes, Cardiovascular Risks, and Lipoproteins、Cardiovascular Health and Disease Prevention、Adipokines, Inflammation, and Metabolic Diseases

Background Carotid atherosclerosis, especially the rupture of unstable plaques, plays an important role in the development of stroke. A novel lipid ratio, the non-high-density lipoprotein cholesterol (non-HDL-C)/high-density lipoprotein cholesterol (HDL-C) ratio, contains both atherogenic and anti-atherogenic particle information, and has been shown to be associated with carotid atherosclerosis. However, there is no data on evaluating the association between non-HDL-C/HDL-C ratio and carotid plaque stability. Methods This study was carried out on 27,436 urban workers aged 20 years or older who participated in a comprehensive health screening between January 2016 and December 2017. Carotid plaque stability was assessed using ultrasonography. Multinomial logistic regression models were used to explore the relationship between the non-HDL-C/HDL-C ratio and carotid plaque stability by odds ratios ( ORs ) and 95% confidence intervals ( CIs ). Subgroup and sensitivity analyses were performed to verify the robustness of the results. Results Carotid plaque was detected in 7,161 (26.1%) participants, with stable and unstable plaque accounting for 3,277 (11.9%) and 3,884 (14.2%), respectively. The prevalence of stable carotid plaque substantially increased with increasing non-HDL-C/HDL-C ratio quartile levels ( p for trend < 0.001) and with a similar association for unstable carotid plaque ( p for trend < 0.001). The mean non-HDL-C/HDL-C ratios (mean ± SD ) of non-carotid plaque (2.9 ±...