Aberrant gray matter volume and functional connectivity in Parkinson’s disease with minor hallucination

作者：Min Zhong, Chenglin Li, Hongquan Lu, Donghui Xue, Yaxi Wang, Yinyin Jiang, Sha Zhu, Ruxin Gu, Xu Jiang, Bo Shen, Jun Zhu, Wenbin Zhang, Yang Pan, Jun Yan, Li Zhang · 发表于：Frontiers in Aging Neuroscience · 年份：2022 · DOI：10.3389/fnagi.2022.923560 · 被引用次数：13 · 研究领域：Parkinson's Disease Mechanisms and Treatments、Functional Brain Connectivity Studies、Transcranial Magnetic Stimulation Studies

Background Minor hallucination (MH) is the most common psychotic symptom in Parkinson’s disease (PD); it can develop into well-structured visual hallucination (VH), suggesting that MH may be a staccato form of well-structured VH. However, it remains unclear whether the pathogenesis is the same. Therefore, the aim of this study was to investigate the altered gray matter volume (GMV) and functional connectivity (FC) of MH in PD to further understand the complex mechanisms. Materials and methods We included 67 PD patients who attended the outpatient clinic of Nanjing Medical University Affiliated Brain Hospital and recruited 31 healthy controls (HC). Demographic data and clinical characteristics of all subjects were recorded, and cranial structural magnetic resonance imaging (MRI) and resting-state functional MRI data were acquired. Patients were classified into the PD with MH (PD-MH) group and PD without hallucinations or delusions (PD-NH) group. Voxel-based morphometry was used to analyze the differences in GMV in the structural pattern. Seed-based FC was used to analyze the functional pattern. Gaussian random field correction was used, with voxel level P < 0.001 and cluster level P < 0.05 representing statistically significant differences. Finally, the correlation between FC values and scores on the clinical characteristics assessment scale was analyzed. Results In the GMV analysis, compared to the PD-NH group, the PD-MH group had reduced GMV in the medial super...