Near-Infrared Turn-On Fluorescent Probe for Aqueous Fluoride Ion Detection and Cell Imaging

作者：Yan Liu, Yaping Zhou, Hongyu Li, Jie Gao, Mingyan Yang, Zeli Yuan, Xinmin Li · 发表于：ACS Omega · 年份：2022 · DOI：10.1021/acsomega.2c03875 · 被引用次数：34 · 研究领域：Molecular Sensors and Ion Detection、Luminescence and Fluorescent Materials、Nanoplatforms for cancer theranostics

Fluoride ions are one of the most essential anions in the human body and have been implicated in various pathological and physiological processes. The detection of fluoride ions in aqueous solution, as well as the imaging of fluoride ions in living cells, remains a challenge. We herein report a BODIPY-based fluorescent probe employing a pinacol borate group as the recognition moiety for the detection of fluoride ions in aqueous solutions. This probe shows high selectivity and sensitivity to fluoride ions with a significant near-infrared fluorescence turn-on response. In addition, this probe was successfully employed in fluorescence bioimaging of fluoride ions in the human cervical cancer cell and mouse mammary cancer cell, demonstrating its good cell permeability and stability under physiological conditions.