Biologics‐Loaded Photothermally Dissolvable Hyaluronic Acid Microneedle Patch for Psoriasis Treatment

作者：Dan Wu, Xin Shou, Yunru Yu, Xiaocheng Wang, Guopu Chen, Yuanjin Zhao, Lingyun Sun · 发表于：Advanced Functional Materials · 年份：2022 · DOI：10.1002/adfm.202205847 · 被引用次数：98 · 研究领域：Advancements in Transdermal Drug Delivery、Dermatology and Skin Diseases、Allergic Rhinitis and Sensitization

Abstract Emerging biologics, such as monoclonal antibodies (mAbs), are the most promising treatment for psoriasis, while their effective delivery to the local inflammatory area of the skin is a challenge. Here, a novel photo‐thermally dissolvable hyaluronic acid microneedle patch is presented with biologics IL‐17 mAbs and MXene encapsulation for psoriasis treatment. As the microneedles possess suitable mechanical strength and great biocompatibility, they can puncture the skin with minimal immune response. In addition, owing to the advantages of superior photothermal conversion efficiency of MXene additive, the microneedle patch can rapidly melt and release the encapsulated IL‐17 mAbs into the dermis under near‐infrared light irradiation for effective anti‐inflammatory effect around the psoriasis lesions. Based on these features, the multifunctional microneedle patch can effectively reduce psoriasis‐like skin inflammation in an imiquimod‐induced animal model, resulting in a desired therapeutic effect. Thus, the proposed microneedle delivery system provides a safer and effective strategy for psoriasis treatment, which is also valuable to improve the clinical efficacy of biologics‐based treatment for other chronic inflammatory autoimmune diseases.