An advanced LC–MS/MS protocol for simultaneous detection of pharmaceuticals and personal care products in the environment

作者：Wenrui Yao, Jinfeng Ge, Qiaozhuan Hu, Jingying Ma, Daohe Yuan, Xiaoli Fu, Yulin Qi, Dietrich A. Volmer · 发表于：Rapid Communications in Mass Spectrometry · 年份：2022 · DOI：10.1002/rcm.9397 · 被引用次数：23 · 研究领域：Pharmaceutical and Antibiotic Environmental Impacts、Analytical chemistry methods development、Effects and risks of endocrine disrupting chemicals

RATIONALE: The development of appropriate analytical screening techniques for pharmaceuticals and personal care products (PPCPs) is the basis for studying the distribution and environmental impact of emerging contaminants (ECs). Mass spectrometry-based screening methods vary with the complexity of the target compounds. It is challenging to balance both positive and negative ion quantification with a low detection limit. To establish a set of experimental methods including extraction, chromatography-separation and mass spectrometry screening is one of the most important topics in PPCP research. This paper describes a universal and efficient qualification and quantification protocol for the simultaneous detection of 34 PPCPs in different environmental samples in a single analytical data acquisition run. METHODS: Thirty-four representative PPCPs, which are widely distributed in the environment with high ecological toxicity and complex chemical structures, were selected as representative target ECs. The extraction of the target PPCPs was achieved using only one solid-phase extraction cartridge without the need to adjust the pH of samples. The enriched samples were detected by LC-MS/MS in both positive and negative ion modes simultaneously. The protocol was evaluated based on the accuracy, precision, detection limits and matrix effects. RESULTS: This method achieved simultaneous detection of PPCPs in both positive and negative ion modes, with a single analytical cycle of 12 min. T...