Urolithin A attenuates severity of chronic pancreatitis associated with continued alcohol intake by inhibiting PI3K/AKT/mTOR signaling

作者：Siddharth Mehra, Supriya Srinivasan, Samara P. Singh, Zhiqun Zhou, Vanessa T. Garrido, Iago De Castro Silva, Tulasigeri M. Totiger, Austin R. Dosch, Xizi Dai, Rajinder Kumar Dawra, Venkatakrishna Rao Jala, Chanjuan Shi, Jashodeep Datta, Michael Nathan VanSaun, Nipun B. Merchant, Nagaraj S. Nagathihalli · 发表于：American Journal of Physiology-Gastrointestinal and Liver Physiology · 年份：2022 · DOI：10.1152/ajpgi.00159.2022 · 被引用次数：25 · 研究领域：Pancreatitis Pathology and Treatment、Apelin-related biomedical research、Kruppel-like factors research

Our novel findings presented here demonstrate the utility of Uro A as an effective therapeutic agent in attenuating alcoholic chronic pancreatitis (ACP) severity with alcohol continuation after established disease, through suppression of the PI3K/AKT/mTOR signaling pathway.