MCM6 is a critical transcriptional target of YAP to promote gastric tumorigenesis and serves as a therapeutic target

作者：Yifei Wang, Huarong Chen, Weixin Liu, Huan Yan, Yihan Zhang, Alvin H.K. Cheung, Jinglin Zhang, Bonan Chen, Liang Li, Zhaocai Zhou, Chi Chun Wong, William Ka Kei Wu, Michael W.Y. Chan, Alfred Sze‐Lok Cheng, Brigette Ma, Jun Yu, Kwok Wai Lo, Ka‐Fai To, Wei Kang · 发表于：Theranostics · 年份：2022 · DOI：10.7150/thno.75431 · 被引用次数：43 · 研究领域：Hippo pathway signaling and YAP/TAZ、Cancer-related gene regulation、Kruppel-like factors research

Hyperactivated YAP in GC induces MCM6 transcription via binding to its promoter. YAP-MCM6 axis facilitates GC progression by inducing PI3K/Akt signaling. Targeting MCM6 suppresses GC growth and sensitizes GC cells to genotoxic agents by modulating ATR/Chk1-dependent DDR, providing a promising strategy for GC treatment.