Association of Daily Step Count and Intensity With Incident Dementia in 78 430 Adults Living in the UK

作者：Borja del Pozo Cruz, Matthew N. Ahmadi, Sharon Linda Naismith, Emmanuel Stamatakis · 发表于：JAMA Neurology · 年份：2022 · DOI：10.1001/jamaneurol.2022.2672 · 被引用次数：188 · 研究领域：Dementia and Cognitive Impairment Research、Older Adults Driving Studies、Balance, Gait, and Falls Prevention

Importance: Step-based recommendations may be appropriate for dementia-prevention guidelines. However, the association of step count and intensity with dementia incidence is unknown. Objective: To examine the dose-response association between daily step count and intensity and incidence of all-cause dementia among adults in the UK. Design, Setting, and Participants: UK Biobank prospective population-based cohort study (February 2013 to December 2015) with 6.9 years of follow-up (data analysis conducted May 2022). A total of 78 430 of 103 684 eligible adults aged 40 to 79 years with valid wrist accelerometer data were included. Registry-based dementia was ascertained through October 2021. Exposures: Accelerometer-derived daily step count, incidental steps (less than 40 steps per minute), purposeful steps (40 steps per minute or more), and peak 30-minute cadence (ie, mean steps per minute recorded for the 30 highest, not necessarily consecutive, minutes in a day). Main Outcomes and Measures: Incident dementia (fatal and nonfatal), obtained through linkage with inpatient hospitalization or primary care records or recorded as the underlying or contributory cause of death in death registers. Spline Cox regressions were used to assess dose-response associations. Results: The study monitored 78 430 adults (mean [SD] age, 61.1 [7.9] years; 35 040 [44.7%] male and 43 390 [55.3%] female; 881 [1.1%] were Asian, 641 [0.8%] were Black, 427 [0.5%] were of mixed race, 75 852 [96.7%] were Wh...