“Drug–Coformer–Drug” Multicomponent Crystals to Simultaneously Improve the Solubility of Two Insoluble Combined Drugs by Introduction of a Soluble Coformer

作者：Bo-Ying Ren, Xia-Lin Dai, Fang Zhang, Xiang-Tian Long, Yong‐Liang Huang, Jia‐Mei Chen, Tong‐Bu Lu · 发表于：Crystal Growth & Design · 年份：2022 · DOI：10.1021/acs.cgd.2c00377 · 被引用次数：10 · 研究领域：Crystallization and Solubility Studies、Innovative Microfluidic and Catalytic Techniques Innovation、Crystallography and molecular interactions

One “drug–drug” ( GTB–RH ) and two “drug–coformer–drug” ( GTB–SA–RH and GTB–SA–RH·EtOH ) multicomponent crystals involving two insoluble drugs, gefitinib (GTB) and rhein (RH), and succinic acid (SA) as a soluble coformer, were successfully obtained. GTB–SA–RH and GTB–SA–RH·EtOH exhibit higher solubility and faster dissolution rates of both GTB and RH as compared to GTB–RH . This study presents an opportunity for simultaneously and effectively improving the solubility of two insoluble drugs by the introduction of a soluble coformer to construct “drug–coformer–drug” multicomponent crystals to develop improved combined medicines.