Development of a novel phosphoramidite-selenide ligand for Pd-catalyzed asymmetric allylic substitution

作者：Bin Feng, Pei-Wen Fang, Gui-Man Lan, Li‐Yan Peng, Lu-Fang Liang, Ge-Yun You · 发表于：Organic & Biomolecular Chemistry · 年份：2022 · DOI：10.1039/d2ob01249a · 被引用次数：17 · 研究领域：Asymmetric Synthesis and Catalysis、Asymmetric Hydrogenation and Catalysis、Chemical Synthesis and Analysis

A novel chiral P,Se-heterodonor ligand has been designed and prepared through an efficient and simple operation. This ligand can be successfully applied to Pd-catalyzed asymmetric allylic substitution with C- and N-nucleophiles, producing a diverse range of chiral allylic products in high yields and enantioselectivities (up to 99% yield and 95% ee).