Effect of chitooligosaccharides with a specific degree of polymerization on multiple targets in T2DM mice

作者：Jiangshan You, Mengyao Zhao, Shumin Chen, Lihua Jiang, Shuhong Gao, Hao Yin, Liming Zhao · 发表于：Bioresources and Bioprocessing · 年份：2022 · DOI：10.1186/s40643-022-00579-3 · 被引用次数：10 · 研究领域：Studies on Chitinases and Chitosanases、Nanocomposite Films for Food Packaging、Aquaculture Nutrition and Growth

Chitooligosaccharides (COS) are found naturally in the ocean and present a variety of physiological activities, of which hypoglycemic action has attracted considerable research attention. This study aimed to assess the therapeutic effect of COS on mice suffering from type 2 diabetes mellitus (T2DM). COS effectively reduced blood glucose and blood lipid levels and improved glucose tolerance. Furthermore, COS revealed strong inhibitory activity against α-glucosidase, reducing postprandial blood glucose levels. Molecular docking data showed that COS might interact with surrounding amino acids to form a complex and decrease α-glucosidase activity. Additionally, COS enhanced insulin signal transduction and glycogen synthesis while restricting gluconeogenesis in the liver and muscles, reducing insulin resistance (IR) as a result. Moreover, COS effectively protected and restored islet cell function to increase insulin secretion. These results indicated that COS exhibited a significant hypoglycemic effect with multi-target participation. Therefore, COS may serve as a new preventive or therapeutic drug for diabetes to alleviate metabolic syndrome.