Physical growth and intelligence development of discordant dizygotic twins from birth to preschool age: a prospective cohort study

作者：Huiqiu Xiang, Xianping Huang, Jing Zhu, Jiajia Chen, Pangpang Zhou, Tong Zhou, Jiale Bao, Zhangye Xu · 发表于：˜The œItalian Journal of Pediatrics/Italian journal of pediatrics · 年份：2022 · DOI：10.1186/s13052-022-01354-y · 被引用次数：3 · 研究领域：Assisted Reproductive Technology and Twin Pregnancy、Cognitive Abilities and Testing、Infant Development and Preterm Care

BACKGROUND: The majority of studies are limited to adverse perinatal outcomes and poor cognitive abilities in the short term in discordant monochorionic twins. METHODS: To determine whether small and large discordant dizygotic twins differ in physical growth and intelligence development and weight and height from birth up to 6 years of age were measured in 34 dizygotic twin pairs with ≥ 20% birth weight discordance. Mental developmental index (MDI) and psychomotor developmental index (PDI) were calculated at 1 year, while the Wechsler Intelligence Scale for Children-IV (WISC-IV) full-scale intelligence quotient (IQ) was assessed at the age of 6. RESULTS: The difference in height and weight in each stage differed significantly from birth to 72-months-old (P < 0.05), although there was disappointing catch-up growth in smaller twins. PDI but not MDI at 1 year of age was significantly different between the two groups (P < 0.05), and smaller twins experienced higher psychomotor retardation rates (P < 0.05). Also, the influence of height and weight on PDI was statistically significant (P < 0.05). No significant difference was detected in the WISC-IV full-scale IQ at the age of 6; however, the full-scale IQ may be affected by the history of suffocation and the S/D value (P = 0.011, P = 0.022). CONCLUSIONS: Intrauterine fetal growth and development lead to birth weight differences in twins and sustain an impact on the children's physical growth in height and weight from birth to pres...