Clinical characteristics of monkeypox virus infections among men with and without HIV : A large outbreak cohort in Germany

作者：Christian Hoffmann, Heiko Jessen, Christoph Wyen, Stephan Grunwald, Sebastian Noé, Jörn Teichmann, Anja‐Sophie Krauss, Henning Kolarikal, Stefan Scholten, Christoph Schuler, Markus Bickel, Clemens Roll, Peter Kreckel, Siegfried Köppe, Matthias Straub, Gerd Klausen, Johannes Lenz, Stefan Esser, Björn‐Erik Ole Jensen, Michael Allen Rausch, Stefan Achim Unger, Ramona Pauli, Georg Härter, Matthias C. Müller, Anja Masuhr, Guido Schäfer, Ulrich Seybold, Sven Schellberg, Jochen Schneider, Malte B. Monin, Eva Wolf, Christoph D. Spinner, Christoph Boesecke · 发表于：HIV Medicine · 年份：2022 · DOI：10.1111/hiv.13378 · 被引用次数：114 · 研究领域：Poxvirus research and outbreaks、Herpesvirus Infections and Treatments、Polyomavirus and related diseases

BACKGROUND: Since May 2022, increasing numbers of monkeypox virus (MPXV) infections have been reported from across Europe and North America. Studies, mainly from Africa, have suggested a higher risk for severe MPXV cases in people living with HIV. METHODS: This was a retrospective study of all confirmed MPXV infections observed in the participating centres since 19 May 2022. We conducted a chart review to evaluate clinical characteristics, comorbidities, and coinfections, including HIV, viral hepatitis, and sexually transmitted infections (STIs). RESULTS: By 30 June 2022, a total of 546 MPXV infections were reported from 42 German centres. All patients were men who have sex with men (MSM), of whom 256 (46.9%) were living with HIV, mostly with a preserved immune system and with viral suppression. In total, 232 (42.5%) MSM were also taking HIV pre-exposure prophylaxis (PrEP) and 58 (10.6%) MSM had no known HIV infection or PrEP use. The median age was 39 years (range 20-67), and comorbidities were rare. However, 52.4% and 29.4% of all patients had been diagnosed with at least one STI within the last 6 months or within the last 4 weeks, respectively. The most frequent localizations of MPXV infection were genital (49.9%) and anal (47.9%), whereas fever (53.2%) and lymphadenopathy (42.6%) were the most frequent general symptoms. The hospitalization rate was low (4.0%), and no fatal course was observed. The clinical picture showed no apparent differences between MSM with or without...