Dynamics of T follicular helper cells in patients with rheumatic diseases and subsequent antibody responses in a three‐dose immunization regimen of CoronaVac

作者：Xingyu Zhou, Yifan Wang, Bo Huang, Ruiling Feng, Xinyao Zhou, Chun Li, Xia Zhang, Miao Shao, Yuzhou Gan, Yuebo Jin, Yuan An, Xian Xiao, Shiyang Wang, Qinghong Liu, Gong Cheng, Fengyunzhi Zhu, Kai Zhang, Naidi Wang, Xiaoyan Xing, Ru Li, Yuhui Li, Yisi Liu, Yisi Liu, Dan Lü, Xiaolin Sun, Zhanguo Li, Yudong Liu, Yudong Liu, Jing He · 发表于：Immunology · 年份：2022 · DOI：10.1111/imm.13572 · 被引用次数：5 · 研究领域：SARS-CoV-2 and COVID-19 Research、T-cell and B-cell Immunology、Immunotherapy and Immune Responses

Given increased acceptance of the CoronaVac, there is an unmet need to assess the safety and immunogenic changes of CoronaVac in patients with rheumatic diseases (RD). Here we comprehensively analysed humoral and cellular responses in patient with RD after a three-dose immunization regimen of CoronaVac. RD patients with stable condition and/or low disease activity (n = 40) or healthy controls (n = 40) were assigned in a 1:1 ratio to receive CoronaVac (Sinovac). The prevalence of anti-receptor binding domain (RBD) antibodies and neutralizing antibodies was similar between healthy control (HC) and RD patients after the second and the third vaccination. However, the titers of anti-RBD IgG and neutralizing antibodies were significantly lower in RD patients compared to HCs (p < 0.05), which was associated with an impaired T follicular helper (Tfh) cell response. Among RD patients, those who generated an antibody response displayed a significantly higher Tfh cells compared to those who failed after the first and the second vaccination (p < 0.05). Interestingly, subjects with a negative serological response displayed a similar Tfh memory response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-derived peptides as their anti-RBD IgG positive counterpart, and all (4/4) of the non-responders in HCs, and 62.5% (5/8) of the non-responders in patients with RD displayed a positive serological response following the third dose. No serious adverse events were observed. In con...