Tandem Synthesis of 1,2,3-Thiadiazoles with 3,4-Dichloroisothiazoles and Hydrazines under External Oxidant- and Sulfur-Free Conditions

作者：Yue Zhang, Kun Li, Wei Gao, Xiaoyu Liu, Haolin Yuan, Liang‐Fu Tang, Zhijin Fan · 发表于：Organic Letters · 年份：2022 · DOI：10.1021/acs.orglett.2c02595 · 被引用次数：10 · 研究领域：Synthesis and biological activity、Sulfur-Based Synthesis Techniques、Synthesis and Biological Evaluation

1,2,3-Thiadiazoles are among the most important heterocyclic motifs, with wide applications in natural products and medicinal chemistry. Herein, we disclose a tandem reaction for the synthesis of structurally diverse 1,2,3-thiadiazoles from 3,4-dichloroisothiazol-5-ketones and hydrazines. This method is characterized by mild external oxidant- and sulter-free reaction conditions, a broad substrate scope, and easy purification.