Palladium-Catalyzed Sequential Heck Reactions of Olefin-Tethered Aryl Iodides with Alkenes

作者：Jia‐Ming Guo, Zhuo‐Ya Mao, Changhong Liu, Shangye Yang, Bang‐Guo Wei · 发表于：The Journal of Organic Chemistry · 年份：2022 · DOI：10.1021/acs.joc.2c01694 · 被引用次数：6 · 研究领域：Catalytic Cross-Coupling Reactions、Catalytic C–H Functionalization Methods、Catalytic Alkyne Reactions

An efficient approach to functionalized ( E )-3-cinnamyl-3-methyl-2,3-dihydrobenzofurans and ( E )-(3-methyl-2,3-dihydrobenzofuran-3-yl)but-2-enones has been developed through a Pd-catalyzed one-pot cascade process involving two sequential Heck reactions, that is, an intramolecular Heck reaction of olefin-tethered aryl iodides and an intermolecular Heck reaction with substituted styrenes and α,β-unsaturated ketones. As a result, a series of desired products were obtained in moderate to good yields and with exclusive E -form selectivities.