Essential Fitness Repertoire of Staphylococcus aureus during Co-infection with Acinetobacter baumannii In Vivo

作者：Gang Li, Wei Shen, Yali Gong, Ming Li, Xiaocai Rao, Qian Liu, Yanlan Yu, Jing Zhou, Keting Zhu, Mengmeng Yuan, Weilong Shang, Yi Yang, Shuguang Lu, Jing Wang, Yan Zhao · 发表于：mSystems · 年份：2022 · DOI：10.1128/msystems.00338-22 · 被引用次数：22 · 研究领域：Antimicrobial Resistance in Staphylococcus、Antibiotic Resistance in Bacteria、Bacterial biofilms and quorum sensing

remain largely unknown. Understanding the polymicrobial composition and interaction, from a community and genome-wide perspective, is thus crucial to shed light on S. aureus pathogenesis strategy. Here, our findings demonstrated, for the first time, that a high incidence rate and clinical relevance of co-infection was caused by S. aureus and Acinetobacter baumannii, illustrating the importance of polymicrobial nature in investigating S. aureus pathogenesis. The infection-type-specific genes likely serve as potential therapeutic targets to control S. aureus infections, either in mono- or co-infection situation, providing novel insights into the development of antimicrobial regimens to control co-infections.