The role of B cells in COVID-19 infection and vaccination

作者：Shiru Chen, Fei Guan, Fabio Candotti, Kamel Benlagha, Niels Olsen Saraiva Câmara, Andrés A. Herrada, Louisa K. James, Jiahui Lei, Heather Miller, Masato Kubo, Qin Ning, Chaohong Liu · 发表于：Frontiers in Immunology · 年份：2022 · DOI：10.3389/fimmu.2022.988536 · 被引用次数：79 · 研究领域：SARS-CoV-2 and COVID-19 Research、COVID-19 Clinical Research Studies、Immunotherapy and Immune Responses

B cells secrete antibodies and mediate the humoral immune response, making them extremely important in protective immunity against SARS-CoV-2, which caused the coronavirus disease 2019 (COVID-19) pandemic. In this review, we summarize the positive function and pathological response of B cells in SARS-CoV-2 infection and re-infection. Then, we structure the immunity responses that B cells mediated in peripheral tissues. Furthermore, we discuss the role of B cells during vaccination including the effectiveness of antibodies and memory B cells, viral evolution mechanisms, and future vaccine development. This review might help medical workers and researchers to have a better understanding of the interaction between B cells and SARS-CoV-2 and broaden their vision for future investigations.