Immobilized copper nanoparticles on biodegradable magnetic starch composite: investigation of its ovarian cancer, cytotoxicity, and antioxidant effects

作者：Ping Hou, Hongyi Kuang, Wei Deng, Yan Lei · 发表于：Journal of Experimental Nanoscience · 年份：2022 · DOI：10.1080/17458080.2022.2110241 · 被引用次数：13 · 研究领域：Advanced Nanomaterials in Catalysis、Nanoparticles: synthesis and applications、Nanoparticle-Based Drug Delivery

In recent days, the green synthesized nanomagnetic biocomposites have been evolved with tremendous potential as the future catalysts. This has encouraged us to design and synthesis of a novel Cu NPs fabricated potato starch functionalized magnetic nanomaterial (Fe3O4@starch/Cu nanocomposite). The prepared nanocomposite were characterized using advanced analytical techniques like FT-IR, FESEM, TEM, EDX, elemental mapping and ICP-OES. The biogenic synthesized Fe3O4@starch/Cu nanocomposite was explored in the anti-ovarian cancer investigations against ovarian cancer cell lines (PA-1, Caov-3, SW 626, and SK-OV-3). The material exhibited significant cytotoxicities against the ovarian cancer cell lines. However, it was considerably inactive against the normal HUVEC cell line. The antioxidant potential of Fe3O4@starch/Cu nanocomposite was also investigated by DPPH method. The Fe3O4@starch/Cu nanocomposite revealed the significant antioxidant potentials according to the IC50 value.