Clinical profiles and antimicrobial resistance patterns of invasive Salmonella infections in children in China

作者：Wen Song, Qing-Wen Shan, Yue Qiu, Xianyao Lin, Chunhui Zhu, Zhiqiang Zhuo, Caihong Wang, Jianning Tong, Rui Li, Chaomin Wan, Yu Zhu, Minxia Chen, Yi Xu, Daojiong Lin, Shouye Wu, Chunmei Jia, Huiling Gao, Junwen Yang, Shiyong Zhao, Mei Zeng, Collaborative Working Group of the Pediatric Subgroup of the China Society of Infectious Diseases · 发表于：European Journal of Clinical Microbiology & Infectious Diseases · 年份：2022 · DOI：10.1007/s10096-022-04476-7 · 被引用次数：19 · 研究领域：Salmonella and Campylobacter epidemiology、Antibiotic Resistance in Bacteria、Trace Elements in Health

Invasive Salmonella infections result in a significant burden of disease including morbidity, mortality, and financial cost in many countries. Besides typhoid fever, the clinical impact of non-typhoid Salmonella infections is increasingly recognized with the improvement of laboratory detection capacity and techniques. A retrospective multicenter study was conducted to analyze the clinical profiles and antimicrobial resistance patterns of invasive Salmonella infections in hospitalized children in China during 2016-2018. A total of 130 children with invasive Salmonella infections were included with the median age of 12 months (range: 1-144 months). Seventy-nine percent of cases occurred between May and October. Pneumonia was the most common comorbidity in 33 (25.4%) patients. Meningitis and septic arthritis caused by nontyphoidal Salmonella (NTS) infections occurred in 12 (9.2%) patients and 5 (3.8%) patients. Patients < 12 months (OR: 16.04) and with septic shock (OR: 23.4), vomit (OR: 13.33), convulsion (OR: 15.86), C-reactive protein (CRP) ≥ 40 g/L (OR: 5.56), and a higher level of procalcitonin (PCT) (OR: 1.05) on admission were statistically associated to an increased risk of developing meningitis. Compared to 114 patients with NTS infections, 16 patients with typhoid fever presented with higher levels of CRP and PCT (P < 0.05). The rates of resistance to ampicillin, sulfamethoxazole/trimethoprim, ciprofloxacin, and ceftriaxone among Salmonella Typhi and NTS isolates were ...