Enantioselective Nickel‐Catalyzed C(sp3)−H Activation of Formamides

作者：Yin‐Xia Wang, Feng‐Ping Zhang, Hao Chen, Yue Li, Jiang‐Fei Li, Mengchun Ye · 发表于：Angewandte Chemie International Edition · 年份：2022 · DOI：10.1002/anie.202209625 · 被引用次数：33 · 研究领域：Catalytic C–H Functionalization Methods、Synthesis and Catalytic Reactions、Asymmetric Hydrogenation and Catalysis

Abstract Enantioselective Ni‐catalyzed C(sp 3 )−H bond activation remains an elusive challenge. Herein, we used phosphine oxide‐ligated Ni−Al bimetallic catalyst to realize enantioselective Ni‐catalyzed aliphatic C(sp 3 )−H activation of formamides, providing a series of chiral N‐containing heterocycles in 40–95 % yield and 70–95 % ee.