Association between serum vitamin D status and the anti-seizure treatment in Chinese children with epilepsy

作者：Na Dong, Hong‐Li Guo, Ya‐Hui Hu, Yang Jiao, Min Xu, Le Ding, Jin‐Chun Qiu, Zhenzhou Jiang, Feng Chen, Xiaopeng Lu, Xiao‐Nan Li · 发表于：Frontiers in Nutrition · 年份：2022 · DOI：10.3389/fnut.2022.968868 · 被引用次数：30 · 研究领域：Pharmacological Effects and Toxicity Studies、Vitamin D Research Studies、Diet and metabolism studies

Objective To compare the serum 25-OH-VitD levels, the major marker of vitamin D (VitD) status, between healthy children and children with epilepsy before initiation of and during anti-seizure medications (ASMs) treatment and to evaluate the potential influence factors on 25-OH-VitD levels. Another major aim was to assess the potential role of VitD supplementation. Methods For comparison, we finally enrolled and collected data from 6,338 healthy children presenting to Health Care Department and 648 children visiting primary care pediatricians with symptoms of epilepsy in Children’s Hospital of Nanjing Medical University from January 2019 to June 2021. The demographic and biochemical characteristics of each child were extracted from the hospital information system. Results Serum 25-OH-VitD levels in 648 children with epilepsy were significantly lower than those of 6,338 healthy children ( P < 0.0001), and the percentage of VitD insufficiency and deficiency status in pediatric patients was 49.19%. Of note, the serum 25-OH-VitD levels in children with newly diagnosed epilepsy before receiving any ASMs treatment were also significantly lower than those in healthy controls. Interestingly, ASMs therapy, alone or in combination, did not consistently reduce baseline serum VitD levels in children with epilepsy. The lower serum VitD levels in pediatric patients than those in healthy children might be related to the disease itself, rather than the ASMs treatment. As expected, VitD...