Elastic Nanovaccine Enhances Dendritic Cell‐Mediated Tumor Immunotherapy (Small 32/2022)

作者：Qiang Li, Zhaogang Teng, Jun Tao, Wenhui Shi, Guangwen Yang, Yu Zhang, Xiaodan Su, Lin Chen, Weijun Xiu, Lihui Yuwen, Heng Dong, Yongbin Mou · 发表于：Small · 年份：2022 · DOI：10.1002/smll.202270173 · 被引用次数：3 · 研究领域：Cancer Immunotherapy and Biomarkers、Nanoplatforms for cancer theranostics、Cancer Research and Treatments

Elastic Nanovaccines In article number 2201108, Zhaogang Teng, Heng Dong, Yongbin Mou, and co-workers report a soft mesoporous organosilica-based nanovaccine (SMONV) and demonstrate that elastic SMONV evokes robust antitumor immune cascades, including lymphatic drainage, antigen internalization and cross-presentation, and tumor-specific T-cell immune responses. Treg-mediated immunosuppression is inhibited after immunization with SMONV. Furthermore, combined administration of anti-PD-L1 antibodies induces tumor regression. The paper provides insight into nanoparticle elasticity and dendritic cell-mediated immunotherapy.