Dynamic regional homogeneity alterations and cognitive impairment in patients with moderate and severe obstructive sleep apnea

作者：Kunyao Li, Yongqiang Shu, Xiang Liu, Wei Xie, Panmei Li, Linghong Kong, Pengfei Yu, Yaping Zeng, Ling Huang, Ting Long, Li Zeng, Haijun Li, Dechang Peng · 发表于：Frontiers in Neuroscience · 年份：2022 · DOI：10.3389/fnins.2022.940721 · 被引用次数：15 · 研究领域：Obstructive Sleep Apnea Research、Functional Brain Connectivity Studies、Neuroscience of respiration and sleep

Background and purpose: Previous studies have found that abnormal local spontaneous brain activity in patients with obstructive sleep apnea (OSA) was associated with cognitive impairment, and dynamic functional connections can capture the time changes of functional connections during magnetic resonance imaging acquisition. The purpose of this study was to investigate the dynamic characteristics of regional brain connectivity and its relationship with cognitive function in patients with OSA and to explore whether the dynamic changes can be used to distinguish them from healthy controls (HCs). Methods: -test was used to test the difference in the dReHo map between OSA patients and HCs. We explored the relationship between dReHo and clinical and cognitive function in OSA patients using Pearson correlation analysis. A support vector machine was used to classify the OSA patients and HCs based on abnormal dReHo. Result: Compared with HCs, OSA patients exhibited higher dReHo values in the right medial frontal gyrus and significantly lower dReHo values in the right putamen, right superior temporal gyrus, right cingulate gyrus, left insula and left precuneus. The correlation analysis showed that the abnormal dReHo values in multiple brain regions in patients with OSA were significantly correlated with nadir oxygen saturation, the oxygen depletion index, sleep period time, and Montreal cognitive assessment score. The support vector machine classification accuracy based on the dReHo dif...