COVID-19 postacute care major organ damage: a systematic review

作者：Nancy Greer, Bradley A. Bart, Charles J. Billington, Susan J. Diem, Kristine E. Ensrud, Anjum S. Kaka, Mark Klein, Anne C. Melzer, Scott Reule, Aasma Shaukat, Kerry M. Sheets, Jamie Starks, Orly Vardeny, Lauren McKenzie, Benjamin Stroebel, Roderick MacDonald, Katie Sowerby, Wei Duan‐Porter, Timothy J Wilt · 发表于：BMJ Open · 年份：2022 · DOI：10.1136/bmjopen-2022-061245 · 被引用次数：12 · 研究领域：COVID-19 Clinical Research Studies、COVID-19 and healthcare impacts、Long-Term Effects of COVID-19

BACKGROUND: Major organ complications have been reported in patients hospitalised for COVID-19; most studies lacked controls. OBJECTIVE: Examine major organ damage postdischarge among adults hospitalised for COVID-19 versus non-COVID-19 controls. DATA SOURCES: MEDLINE, Embase and Cochrane Library from 1 January 2020 to 19 May 2021. STUDY ELIGIBILITY CRITERIA: English language studies of adults discharged from hospital for COVID-19; reporting major organ damage. Single review of abstracts; independent dual review of full text. STUDY APPRAISAL AND SYNTHESIS METHODS: Study quality was assessed using the Joanna Briggs Institute Appraisal Checklist for Cohort Studies. Outcome data were not pooled due to heterogeneity in populations, study designs and outcome assessment methods; findings are narratively synthesised. RESULTS: Of 124 studies in a full evidence report, 9 included non-COVID controls and are described here. Four of the nine (three USA, one UK) used large administrative databases. Four of the remaining five studies enrolled <600 COVID-19 patients. Mean or median age ranged from 49 to 70 years with 46%-94% male and 48%-78% White race; 10%-40% had been in intensive care units. Follow-up ranged from 4 weeks to 22 weeks postdischarge. Four used hospitalised controls, three non-hospitalised controls and two were unclear. Studies used various definitions of, and methods to assess, major organ damage outcomes. While the magnitude of effect differed across studies, incident card...