DNA compaction and dynamic observation in a nanopore gated sub-attoliter silicon nanocavity

作者：Shuangshuang Zeng, Mauro Chinappi, Fabio Cecconi, Theo Odijk, Zhen Zhang · 发表于：Nanoscale · 年份：2022 · DOI：10.1039/d2nr02260e · 被引用次数：10 · 研究领域：Nanopore and Nanochannel Transport Studies、Microfluidic and Capillary Electrophoresis Applications、Ion-surface interactions and analysis

ionic current measurements. The mechanism for the DNA compaction is elucidated by varying the DNA length or concentration, voltage polarity, nanocavity dimensions and ionic strength. Furthermore, Brownian dynamics simulations reveal the dynamic fluctuations of the compacted DNA, which are reflected in the measured ionic current. Our nanocavity device is anticipated to provide a controlled environment in extremely small volumes for investigating the physics of confined biopolymers.