Safety and feasibility of neoadjuvant chemotherapy as a surgical bridge for acute left-sided malignant colorectal obstruction : a retrospective study

作者：Jiawei Zhang, J. S. Deng, Jiancong Hu, Qinghua Zhong, Juan Li, Mingli Su, Wei Liu, Miwei Lv, Tian Xu, Dezheng Lin, Xuefeng Guo · 发表于：Research Square · 年份：2022 · DOI：10.21203/rs.3.rs-1642460/v1 · 被引用次数：1 · 研究领域：Colorectal Cancer Surgical Treatments、Colorectal and Anal Carcinomas、Intraperitoneal and Appendiceal Malignancies

Abstract Background: For colorectal cancer, preoperative (neoadjuvant) chemotherapy is more effective than postoperative chemotherapy because it eradicates micrometastases more effectively and reduces the risk of incomplete intraoperative resection and tumor cell shedding. For the treatment of acute left-sided malignant colorectal obstruction, colorectal stents as well as stoma are being used to relieve the obstructive colorectal cancer, and as a bridge to surgery, allowing easy mobilization and resection of the colon. Neoadjuvant chemotherapy combined with self-expanding metal stents or neoadjuvant chemotherapy combined with stoma can be used as a bridge to elective surgery as an alternative to emergency surgery in patients with acute left-sided malignant colorectal obstruction, but its benefit is uncertain. The purpose of this study was to evaluate the safety and feasibility of neoadjuvant chemotherapy as a bridge to surgery in the treatment of acute left-sided malignant colorectal obstruction. Methods: Data from patients who were admitted withacute left-sided malignant colorectal obstruction between January 2012 and December 2020 were retrospectively reviewed；Patients with peritonitis or bowel perforation were excluded. We performed one-to-two propensity score matching to compare the stoma requirement, postoperative complications, and other short-term oncological outcomes between the neoadjuvant chemotherapy group and surgery groups. Results: There were no differences in i...