Estimating the causal effect of frailty index on vestibular disorders: A two-sample Mendelian randomization

作者：Gui Xiao, Hu Wang, Jiaji Hu, Li Liu, Tingting Zhang, Mengjia Zhou, Xingxing Li, Chunxiang Qin · 发表于：Frontiers in Neuroscience · 年份：2022 · DOI：10.3389/fnins.2022.990682 · 被引用次数：14 · 研究领域：Vestibular and auditory disorders、Frailty in Older Adults、Balance, Gait, and Falls Prevention

Background Frailty index and vestibular disorders appear to be associated in observational studies, but causality of the association remains unclear. Methods A two-sample Mendelian randomization (MR) study was implemented to explore the causal relationship between the frailty index and vestibular disorders in individuals of European descent. A genome-wide association study (GWAS) of frailty index was used as the exposure ( n = 175, 226), whereas the GWAS of vestibular disorders was the outcome ( n = 462,933). MR Steiger filtering method was conducted to investigate the causal effect of the frailty index on vestibular disorders. An inverse variance weighted (IVW) approach was used as the essential approach to examine the causality. Additionally, the MR-Egger methods, the simple mode analysis, the weighted median analysis, and the weighted mode analysis were used as supplementary methods. The MR-PRESSO analysis, the MR-Egger intercept analysis, and Cochran's Q statistical analysis also were used to detect the possible heterogeneity as well as directional pleiotropy. To evaluate this association, the odds ratio (OR) with 95% confidence intervals (CIs) was used. All statistical analyses were performed in R. The STROBE-MR checklist for the reporting of MR studies was used in this study. Results In total, 14 single nucleotide polymorphisms (SNPs) were identified as effective instrumental variables (IVs) in the two sample MR analyses. The significant causal effect of the frailty ind...