Role of Collagen in Vascular Calcification

作者：Yunyun Zhao, Zhen Sun, Lihua Li, Wei Yuan, Zhongqun Wang · 发表于：Journal of Cardiovascular Pharmacology · 年份：2022 · DOI：10.1097/fjc.0000000000001359 · 被引用次数：27 · 研究领域：Dermatological and Skeletal Disorders、Parathyroid Disorders and Treatments、Bone and Dental Protein Studies

ABSTRACT: Vascular calcification is a pathological process characterized by ectopic calcification of the vascular wall. Medial calcifications are most often associated with kidney disease, diabetes, hypertension, and advanced age. Intimal calcifications are associated with atherosclerosis. Collagen can regulate mineralization by binding to apatite minerals and promoting their deposition, binding to collagen receptors to initiate signal transduction, and inducing cell transdifferentiation. In the process of vascular calcification, type I collagen is not only the scaffold for mineral deposition but also a signal entity, guiding the distribution, aggregation, and nucleation of vesicles and promoting the transformation of vascular smooth muscle cells into osteochondral-like cells. In recent years, collagen has been shown to affect vascular calcification through collagen disc-domain receptors, matrix vesicles, and transdifferentiation of vascular smooth muscle cells.