Associations between maternal prenatal depression and neonatal behavior and brain function – Evidence from the functional near-infrared spectroscopy

作者：Shan Wang, Chenxi Ding, Chengyin Dou, Zeen Zhu, Dan Zhang, Qiqi Yi, Haoyue Wu, Longshan Xie, Zhongliang Zhu, Dongli Song, Hui Li · 发表于：Psychoneuroendocrinology · 年份：2022 · DOI：10.1016/j.psyneuen.2022.105896 · 被引用次数：25 · 研究领域：Maternal Mental Health During Pregnancy and Postpartum、Optical Imaging and Spectroscopy Techniques、Stress Responses and Cortisol

BACKGROUND: Maternal prenatal depression is a significant public health issue associated with mental disorders of offspring. This study aimed to determine if maternal prenatal depressive symptoms are associated with changes in neonatal behaviors and brain function at the resting state. METHODS: A total of 204 pregnant women were recruited during the third trimester and were evaluated by Edinburgh Postpartum Depression Scale (EPDS). The mother-infant pairs were divided into the depressed group (n = 75) and control group (n = 129) based on the EPDS, using a cut-off value of 10. Cortisol levels in the cord blood and maternal blood collected on admission for delivery were measured. On day three of life, all study newborns were evaluated by the Neonatal Behavior Assessment Scale (NBAS) and 165 infants were evaluated by resting-state functional near-infrared spectroscopy (rs-fNIRS). To minimize the influences of potential bias on the rs-fNIRS results, we used a binary logistic regression model to carry out propensity score matching between the depressed group and the control group. Rs-fNIRS data from 21 pairs of propensity score-matched newborns were used for analysis. The associations between maternal EPDS scores, neonatal NBAS scores, and cortisol levels were analyzed using linear regressions and the mediation analysis models. RESULTS: Compared to the control group, the newborns in the depressed group had lower scores in the social-interaction and autonomic system dimensions of N...