Clinical significance of potential drug–drug interactions in older adults with psychiatric disorders: a retrospective study

作者：Yu Liu, Man Yang, Yaping Ding, Huanqiang Wang, Hailin Zhang, Hailin Zhang, Dandan Wang, Tianchi Zhuang, Minghui Ji, Yan Cui, Hong Wang, Hong Wang · 发表于：BMC Psychiatry · 年份：2022 · DOI：10.1186/s12888-022-04207-4 · 被引用次数：11 · 研究领域：Pharmaceutical Practices and Patient Outcomes、Schizophrenia research and treatment、Pharmacovigilance and Adverse Drug Reactions

BACKGROUND: Polypharmacy increases the risk of potential drug-drug interactions (pDDIs). This retrospective analysis was conducted to detect pDDIs and adverse drug reactions (ADRs) among older adults with psychiatric disorder, and identify pDDIs with clinical significance. METHODS: A retrospective analysis was carried out based on the medical records of older adults with psychiatric disorders. Data on demographic characteristics, substance abuse, medical history, and medications were extracted. The Lexi-Interact online database was used to detect pDDIs. The minimal clinically important difference (MCID) was set as the change in the Treatment Emergent Symptom Scale (TESS) score between admission and discharge. The median and interquartile ranges were used for continuous variables, and frequencies were calculated for dichotomous variables. Poisson regression was implemented to determine the factors influencing the number of ADR types. The influencing factors of each ADR and the clinical significance of the severity of the ADR were analysed using binary logistic regression. P < 0.05 was considered statistically significant. RESULTS: A total of 308 older adults were enrolled, 171 (55.52%) of whom had at least 1 pDDI. Thirty-six types of pDDIs that should be avoided were found, and the most frequent pDDI was the coadministration of lorazepam and olanzapine (55.5%). A total of 26 ADRs induced by pDDIs were identified, and the most common ADR was constipation (26.05%). There was a 9...