Adverse drug reactions and correlations with drug–drug interactions: A retrospective study of reports from 2011 to 2020

作者：Huaqiao Jiang, Yanhua Lin, Weifang Ren, Zhonghong Fang, Yujuan Liu, Xiaofang Tan, Xiaoqun Lv, Ning Zhang · 发表于：Frontiers in Pharmacology · 年份：2022 · DOI：10.3389/fphar.2022.923939 · 被引用次数：85 · 研究领域：Pharmacovigilance and Adverse Drug Reactions、Pharmaceutical studies and practices、Pharmaceutical Economics and Policy

Introduction: Adverse drug reactions (ADRs) represent a public health problem worldwide that deserves attention due to the impact on mortality, morbidity, and healthcare costs. Drug–drug interactions (DDIs) are an important contributor to ADRs. Most of the studies focused only on potential DDIs (pDDIs), while the detailed data are limited regarding the ADRs associated with actual DDIs. Methods: This retrospective study evaluated ADRs reported between 2011 and 2020 in a tertiary hospital. The causality and severity of ADRs were evaluated through the Naranjo Algorithm and Hartwig’s scale, respectively. Preventability classification was based on the modified Schoumock and Thornton scale. For ADRs with at least two suspected drugs, pDDIs were identified according to the Lexi-Interact. We further checked whether the ADR description in the reports corresponded to the clinical consequences of the pDDIs. Results: A total of 1,803 ADRs were reported, of which 36.77% ADRs were classified as mild, 43.26% as moderate, and 19.97% as severe. The assessment of causality showed that the distributions of definite, probable, and possible categories were 0.33%, 58.68%, and 40.99%, respectively. A total of 53.97% of ADRs were identified as preventable ADRs, while 46.03% were recognized as unpreventable. The severity of ADRs was significantly correlated with age, the number of suspected drugs and preventability. Antimicrobial agents were the most common implicated pharmacological group, and the m...