Changing genetic architecture of body mass index from infancy to early adulthood: an individual based pooled analysis of 25 twin cohorts

作者：Karri Silventoinen, Weilong Li, Aline Jelenkovic, Reijo Sund, Yoshie Yokoyama, Sari Aaltonen, Maarit Piirtola, Masumi Sugawara, Mami TANAKA, Satoko Matsumoto, Laura A. Baker, Catherine Tuvblad, Per Tynelius, Finn E Rasmussen, Jeffrey Mark Craig, Richard Saffery, Gonneke A. H. M. Willemsen, Meike Bartels, Catharina E. M. van Beijsterveldt, Nicholas G. Martin, Sarah Elizabeth Medland, Grant W. Montgomery, Paul Lichtenstein, Robert Frank Krueger, Matt K. McGue, Shandell Pahlen, Kaare Christensen, Axel Skytthe, Kirsten Ohm Kyvik, Kimberly J. Saudino, Lise Dubois, Michel Boivin, Mara R. Brendgen, Ginette Dionne, Frank Vitaro, Vilhelmina Ullemar, Catarina Almqvist, Patrik K. E. Magnusson, Robin P. Corley, Brooke M. Huibregtse, Ariel Knafo‐Noam, David Mankuta, Lior Abramson, Claire M. A. Haworth, Robert J. Plomin, Morten Bjerregaard-Andersen, Henning Beck‐Nielsen, Morten Sodemann, Glen E. Duncan, Dedra Buchwald, Sybil Alexandra Burt, Kelly L. Klump, Clare Heidi Llewellyn, Abigail M. Fisher, Dorret Irene Boomsma, Thorkild I. A. Sørensen, Jaakko A. Kaprio · 发表于：International Journal of Obesity · 年份：2022 · DOI：10.1038/s41366-022-01202-3 · 被引用次数：37 · 研究领域：Genetic Associations and Epidemiology、Cognitive Abilities and Testing、Obesity, Physical Activity, Diet

BACKGROUND: Body mass index (BMI) shows strong continuity over childhood and adolescence and high childhood BMI is the strongest predictor of adult obesity. Genetic factors strongly contribute to this continuity, but it is still poorly known how their contribution changes over childhood and adolescence. Thus, we used the genetic twin design to estimate the genetic correlations of BMI from infancy to adulthood and compared them to the genetic correlations of height. METHODS: We pooled individual level data from 25 longitudinal twin cohorts including 38,530 complete twin pairs and having 283,766 longitudinal height and weight measures. The data were analyzed using Cholesky decomposition offering genetic and environmental correlations of BMI and height between all age combinations from 1 to 19 years of age. RESULTS: The genetic correlations of BMI and height were stronger than the trait correlations. For BMI, we found that genetic correlations decreased as the age between the assessments increased, a trend that was especially visible from early to middle childhood. In contrast, for height, the genetic correlations were strong between all ages. Age-to-age correlations between environmental factors shared by co-twins were found for BMI in early childhood but disappeared altogether by middle childhood. For height, shared environmental correlations persisted from infancy to adulthood. CONCLUSIONS: Our results suggest that the genes affecting BMI change over childhood and adolescence...