The risk factors of neuropathic pain in neuromyelitis optica spectrum disorder: a retrospective case-cohort study

作者：Xiaojun Li, Haoyou Xu, Zequan Zheng, Huiying Ouyang, Guixian Chen, Zhenzhen Lou, Haoxuan Chen, Jiahui Zhang, Yibo Zhan, Hui Mao, Changlin Zhang, Min Zhao, Yuanqi Zhao · 发表于：BMC Neurology · 年份：2022 · DOI：10.1186/s12883-022-02841-9 · 被引用次数：14 · 研究领域：Multiple Sclerosis Research Studies、Pain Mechanisms and Treatments、Systemic Sclerosis and Related Diseases

BACKGROUND: Neuropathic pain is a common complication in neuromyelitis optica spectrum disorder (NMOSD), which seriously affects the quality of life of NMOSD patients, with no satisfactory treatment. And risk factors of neuropathic pain are still uncertain. OBJECTIVE: To investigate the risk factors of neuropathic pain in a NMOSD cohort. MATERIALS AND METHODS: Our study was a retrospective case-cohort study, the patients diagnosed with NMOSD in the Department of Neurology from the Second Affiliated Hospital of Guangzhou University of Chinese Medicine from January 2011 to October 2021 were screened. Inclusion criteria were: (1) patients diagnosed as NMOSD according to the International Panel for NMO Diagnosis (IPND) criteria, (2) the aquaporin-4 immunoglobulin G antibodies (AQP4-IgG) test was performed. Patients without AQP4-IgG antibody were excluded. Clinical data, including sex, age of the first onset, symptoms of the first episode including neuropathic pain and attack types, localization of lesions of the first episode on Magnetic Resonance Imaging (MRI), Extended disability status Scale (EDSS) of the first onset, treatment of immunosuppression in the first acute phase, disease modifying therapy (DMT), treatment of neuropathic pain and APQ4-IgG status were collected from the hospital system database. Neuropathic pain was defined according to the International Association for the Study of Pain criteria and was described as "pain arising as a direct consequence of a lesion o...