Evaluation and Management of Primary Hyperparathyroidism: Summary Statement and Guidelines from the Fifth International Workshop

作者：John P. Bilezikian, Aliya Khan, Shonni J. Silverberg, Ghada El‐Hajj Fuleihan, Claudio Marcocci, Salvatore Minisola, Nancy D. Perrier, Antonio Sitges‐Serra, Rajesh V. Thakker, Gordon Guyatt, Michael Mannstadt, John T. Potts, B.L. Clarke, Maria Luisa Brandi, On behalf of the International Workshop on Primary Hyperparathyroidism · 发表于：Journal of Bone and Mineral Research · 年份：2020 · DOI：10.1002/jbmr.4677 · 被引用次数：542 · 研究领域：Parathyroid Disorders and Treatments、Pancreatitis Pathology and Treatment、Vitamin D Research Studies

The last international guidelines on the evaluation and management of primary hyperparathyroidism (PHPT) were published in 2014. Research since that time has led to new insights into epidemiology, pathophysiology, diagnosis, measurements, genetics, outcomes, presentations, new imaging modalities, target and other organ systems, pregnancy, evaluation, and management. Advances in all these areas are demonstrated by the reference list in which the majority of listings were published after the last set of guidelines. It was thus, timely to convene an international group of over 50 experts to review these advances in our knowledge. Four Task Forces considered: 1. Epidemiology, Pathophysiology, and Genetics; 2. Classical and Nonclassical Features; 3. Surgical Aspects; and 4. Management. For Task Force 4 on the Management of PHPT, Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) methodology addressed surgical management of asymptomatic PHPT and non-surgical medical management of PHPT. The findings of this systematic review that applied GRADE methods to randomized trials are published as part of this series. Task Force 4 also reviewed a much larger body of new knowledge from observations studies that did not specifically fit the criteria of GRADE methodology. The full reports of these 4 Task Forces immediately follow this summary statement. Distilling the essence of all deliberations of all Task Force reports and Methodological reviews, we offer, in this s...